Key result
The Arg213->Gly mutation in extracellular superoxide dismutase reduces both heparin and collagen affinities by approximately 12-fold compared to the wild-type enzyme.
Population
Purified wild-type human extracellular superoxide dismutase from human aorta, R213G variant EC-SOD purified…
Comparison
Arg213→Gly mutation in extracellular superoxide… vs Wild-type EC-SOD
Design
Preclinical
Authors
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May reduce tissue antioxidant protection in carriers; leaves open whether this drives human cardiovascular risk.
Effect estimate: 12-fold reduction
The R213G mutation in EC-SOD reduces its affinity for both heparin and collagen, providing a biochemical mechanism for the increased plasma concentration of the enzyme and potentially explaining the increased cardiovascular risk in carriers due to reduced tissue antioxidant protection.
Petersen et al. (2005) studied Arg213->Gly mutation in EC-SOD. Arg213->Gly (R213G) mutation vs. Wild-type EC-SOD was evaluated on Heparin and collagen affinity (12-fold reduction). The Arg213->Gly mutation in extracellular superoxide dismutase reduces both heparin and collagen affinities by approximately 12-fold compared to the wild-type enzyme.
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