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December 16, 2016Clinical and Translational ScienceOpen Access

TLR4 and Caveolin‐1 in Monocytes Are Associated With Inflammatory Conditions in Diabetic Neuropathy

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Authors

TZTong ZhuQMQingming MengJJJian Ji

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Overview

Comparative study reveals elevated TLR4 and decreased caveolin-1 in monocytes of diabetic neuropathy patients, suggesting caveolin-1 loss worsens systemic inflammation.

Key Points

  • To investigate the monocyte expression of TLR4 and caveolin-1 and their relationship with inflammatory markers in patients with diabetic peripheral neuropathy compared to diabetic and healthy controls.
  • Enrolled 19 healthy controls, 18 patients with type 2 diabetes mellitus, and 20 patients with diabetic peripheral neuropathy.
  • Quantified monocyte TLR4, caveolin-1, MyD88, total IκB, and phosphorylated IκB, as well as plasma TNF-α and IL-6, using real-time PCR, Western blotting, and ELISA.
  • Monocytes from patients with diabetic peripheral neuropathy exhibited significantly increased expression of TLR4, MyD88, and phosphorylated IκB alongside reduced caveolin-1 and total IκB compared to controls and diabetic patients without neuropathy.
  • Plasma concentrations of TNF-α and IL-6 correlated positively with TLR4 expression and negatively with caveolin-1, while TLR4 also showed a direct negative correlation with caveolin-1 in patients with diabetic peripheral neuropathy.

Cite This Study

Zhu et al. (2016) studied this question.

synapsesocial.com/papers/6a93af0eeea32b7d89ebb65ehttps://doi.org/10.1111/cts.12434
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Also Consider

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