A facile, efficient synthesis of 4‐hydroxy‐2(E)‐nonenal is presented as an alternative to the approaches published previously, which either employed four to six separate steps or furnished low yields. The commercially available 3(Z)‐nonenol was sequentially oxidized into 3,4‐epoxynonanol by 3‐chloroperoxybenzoic acid followed by oxidation of the alcohol by periodinane to afford 4‐hydroxy‐2(E)‐nonenal by this two‐step procedure in 48±7% yield.
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Gardner et al. (1992) studied this question.
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