Key result
Living-donor renal transplantation in a patient on hemodialysis for over 20 years drastically improved cardiac function, increasing left ventricular ejection fraction from 30% to 50% and reducing severe mitral regurgitation to mild.
Why the study?
The feasibility of renal transplantation in patients with low cardiac function remains controversial, despite reports of cardiac recovery.
Case Report (n=1)
No
Living-donor renal transplantation can lead to significant recovery of cardiac function and improvement of severe mitral regurgitation in patients on long-term hemodialysis.
Suggests possible cardiac recovery after renal transplant in long-term hemodialysis; leaves open generalizability beyond single cases.
BACKGROUND: Although there are reports of recovery of cardiac function after renal transplantation, the feasibility of renal transplantation in patients with low cardiac function remains controversial. CASE PRESENTATION: A 59-year-old Japanese male was scheduled to undergo living-donor renal transplantation (LDRT) under general anesthesia. Preoperative transthoracic echocardiography revealed severe mitral regurgitation (MR) and a left ventricular ejection fraction (LVEF) at 30%. LDRT was conducted prior to cardiac surgery with restrictive fluid management and close monitoring of cardiac function. The patient's renal function improved promptly after the LDRT, and his hemodynamics were stable throughout the perioperative period. Along with improvements in the patient's renal function and anemia, the patient's cardiac function improved to LVEF 50% and achieved drastically improved MR as well as cardiac function, without intervention. CONCLUSION: This case indicates that LDRT has the potential to improve cardiac function in patients who have been on hemodialysis for more than 20 years.
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Noguchi et al. (2022) conducted a case report in End-stage renal disease with severe mitral regurgitation (n=1). Living-donor renal transplantation vs. Pre-transplant baseline was evaluated on Improvement in cardiac function (LVEF and MR severity). Living-donor renal transplantation in a patient on hemodialysis for over 20 years drastically improved cardiac function, increasing left ventricular ejection fraction from 30% to 50% and reducing severe mitral regurgitation to mild.
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