Key result
Blood pressure-associated genetic variants were significantly associated with coronary artery disease in East Asian individuals, with the strongest association at ATP2B1 rs2681472 demonstrating a counterintuitive 12% reduction in CAD risk (OR 0.88).
Why the study?
Are genetic loci associated with blood pressure also associated with coronary artery disease in East Asian individuals?
Case-Control (n=17,785)
Yes
Are genetic loci associated with blood pressure also associated with coronary artery disease in East Asian individuals?
A substantial proportion of genetic variants associated with blood pressure are also associated with the risk of coronary artery disease in East Asian populations.
Answers are grounded in this paper and cite their sources.
BP variants link to CAD risk in East Asians; extends trans-ancestry evidence but remains hypothesis-generating without causal or clinical implications.
BACKGROUND: A coronary artery disease (CAD) association study of genetic loci previously identified as being associated with blood pressure (BP) was performed in east Asian populations. METHODS AND RESULTS: Nine single nucleotide polymorphisms (SNPs) from 9 candidate loci robustly confirmed to be associated with BP in east Asian people, were genotyped. Genotyping was done in up to 17,785 CAD case-control samples (6,522 cases and 11,263 controls). We then tested the associations with other metabolic traits (n≤17,900) and with type 2 diabetes (931 cases and 1,404 controls), and looked up the datasets in silico in other populations. Significant (adjusted P<0.05) CAD associations were found for 5 BP loci: 3 new CAD associations at FIGN,FGF5 and NPR3, and 2 previously reported ones at ATP2B1 and CNNM2. The strongest CAD association was detected at ATP2B1rs2681472 (P=1.7×10(-8)), in the direction inverted to what is generally recognized for BP in the epidemiological studies.CNNM2rs12413409 showed significant association with CAD (P=8.7×10(-7)) and BMI (P=3.5×10(-8), when meta-analyzed with 75,807 east Asian people). The genetic risk score combining BP-raising alleles at each of the SNPs was positively associated with CAD (P=0.011). CONCLUSIONS: A substantial proportion of genetic variants associated with BP were also associated with the risk of CAD in east Asian people, and there was some counter-evidence for causal inference.
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Takeuchi et al. (2015) conducted a case-control in Coronary artery disease (n=17,785). Blood pressure-associated genetic loci (9 SNPs) vs. Non-carriers / reference alleles was evaluated on Coronary artery disease (CAD) association at ATP2B1 rs2681472 (OR 0.88, 95% CI 0.84-0.92, p=1.7×10–8). Blood pressure-associated genetic variants were significantly associated with coronary artery disease in East Asian individuals, with the strongest association at ATP2B1 rs2681472 demonstrating a counterintuitive 12% reduction in CAD risk (OR 0.88).
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