Key result
N-acetylhomocysteine thiolactone in the presence of silver successfully introduced sulfhydryl groups into proteins via peptide bonds at room temperature and neutral pH.
May enable mild protein thiolation for cardiovascular research; leaves open in vivo validation and clinical relevance.
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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Benesch et al. (1958) studied this question. N-acetylhomocysteine thiolactone (AHTL) and silver was evaluated. N-acetylhomocysteine thiolactone in the presence of silver successfully introduced sulfhydryl groups into proteins via peptide bonds at room temperature and neutral pH.
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