Key result
The IL28B rs12979860 T allele (TT and CT genotypes) was significantly associated with increased susceptibility to chronic hepatitis C infection compared to the CC genotype (OR 2.195).
Why the study?
Are IL28B gene polymorphisms associated with the establishment of HCV infection and influenced by HIV coinfection?
Case-Control (n=429)
No
Are IL28B gene polymorphisms associated with the establishment of HCV infection and influenced by HIV coinfection?
The rs12979860 C allele and rs8099917 T allele of the IL28B gene are associated with a protective effect against HCV infection, regardless of HIV coinfection status.
Answers are grounded in this paper and cite their sources.
IL28B T allele may heighten HCV susceptibility risk; leaves open HIV coinfection modification in prospective cohorts.
INTRODUCTION: Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the allelic and genotypic variants of the IL28B polymorphisms rs12979860 (C/T) and rs8099917 (T/G) and their possible association with the establishment of HCV infection. METHODOLOGY: A total of 199 non-infected controls and 230 patients with chronic hepatitis C, including 53 coinfected with HIV, participated in the study. Genotyping consisted of polymerase chain reaction and subsequent analysis of the restriction patterns resulting from exposure to endonucleases. RESULTS: Among the controls with established results, 47.4% (90/190) exhibited the rs12979860 CC genotype, 43.7 CT, and 8.9% TT, whereas 29.1% (66/227), 51.5%, and 19.4% of the patients exhibited the CC, CT, and TT genotypes, respectively. With respect to rs8099917, 66.8% (133/199) of the controls exhibited the TT genotype, 31.2% TG, and 2.0% GG, whereas 56.1% (129/230), 40.9%, and 3.0% of the patients exhibited the TT, TG, and GG genotypes, respectively. CONCLUSION: The frequencies of the rs12979860 C allele and CC genotype and of the rs8099917 T allele and TT genotype were significantly higher among controls compared with patients, thus confirming the suggested protective effect against HCV infection. No significant difference was observed in the genotype and allelic distributions between the mono- and coinfected patients.
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Bertol et al. (2015) conducted a case-control in Chronic hepatitis C (n=429). IL28B rs12979860 T allele (TT and CT genotypes) vs. IL28B rs12979860 CC genotype was evaluated on Susceptibility to chronic HCV infection (OR 2.195, 95% CI 1.437-3.357, p=<0.001). The IL28B rs12979860 T allele (TT and CT genotypes) was significantly associated with increased susceptibility to chronic hepatitis C infection compared to the CC genotype (OR 2.195).
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