Key result
Primary pleuropulmonary synovial sarcoma presents with non-specific symptoms and requires cytogenetic and molecular studies for diagnostic confirmation.
Why the study?
Primary pleuropulmonary synovial sarcoma is rare, with non-specific presentations and imaging resembling other intrathoracic malignancies that require cytogenetic and molecular confirmation.
This review summarizes the clinical, radiological, and histopathological features of rare primary pleuropulmonary synovial sarcomas to aid in diagnosis.
May aid recognition of rare pleural tumors; extends case literature but leaves prospective validation open.
Primary sarcomas of the lung represent less than 0.5% of all primary lung tumors and comprise a heterogeneous group of malignancies including synovial sarcoma (SS). Primary pleuropulmonary SS has non-specific presentations, such as chest pain, shortness of breath and cough, and its associated imaging features resemble those of other intrathoracic malignancies. The diagnosis of these tumors needs to be confirmed by cytogenetic and molecular studies. Here, we describe two rare cases of primary pleuropulmonary SS who were admitted to our hospital. We also provide a concise review of clinical, radiological, and histopathological characteristics of pleuropulmonary SS after exploring 168 studies (415 corresponding patients) that were identified through a literature search.
No takes yet. Share an insight, caveat, or question.
Khalili et al. (2021) conducted a review in Primary pleuropulmonary synovial sarcoma (n=417). Primary pleuropulmonary synovial sarcoma presents with non-specific symptoms and requires cytogenetic and molecular studies for diagnostic confirmation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: