Decreased right heart blood volume determined by magnetic resonance imaging: Evidence of central underfilling in cirrhosis
Key result
Cirrhosis was associated with significantly reduced right ventricular end-diastolic volume compared to controls (122 vs. 166 mL, P<0.02), indicating central vascular underfilling.
Why the study?
Do cirrhotic patients have reduced or expanded central blood volume and heart cavity volumes compared to matched controls?
Population
10 cirrhotic patients and matched controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports central underfilling in cirrhosis; hypothesis-generating for volume assessment and requires prospective validation.
Study Design
Type
Case-Control (n=20)
Structured PICO
Do cirrhotic patients have reduced or expanded central blood volume and heart cavity volumes compared to matched controls?
P
Population
10 cirrhotic patients and matched controls who underwent magnetic resonance imaging to assess heart cavity volumes.
C
Comparator
Matched controls
O
Outcome
Right and left ventricular end-diastolic volumes (RVDV and LVDV), and end-systolic volumes (RVSV and LVSV) determined by magnetic resonance imaging (MRI)surrogate
Main Result
Absolute Event Rate: 122% vs 166%
p-value: p=<0.02
Cirrhotic patients exhibit central vascular underfilling with reduced right heart blood volume despite a hyperkinetic circulation, suggesting abnormal blood volume distribution.
Cite This Study
Møller et al. (1995) conducted a case-control in Cirrhosis (n=20). Cirrhosis vs. Matched controls was evaluated on Right ventricular end-diastolic volume (RVDV) (p=<0.02). Cirrhosis was associated with significantly reduced right ventricular end-diastolic volume compared to controls (122 vs. 166 mL, P<0.02), indicating central vascular underfilling.