Key result
Higher appendicular skeletal muscle mass index was more strongly and independently associated with lower brachial-ankle pulse wave velocity than body mass index in community-dwelling older adults.
Why the study?
Few studies have examined a dose-response relationship between muscle mass and atherosclerosis in the elderly, and whether this association is stronger than that of BMI remains unknown.
Is appendicular skeletal muscle mass index more strongly associated with atherosclerosis than body mass index in the community-dwelling elderly?
Cross-Sectional (n=995)
Is appendicular skeletal muscle mass index more strongly associated with atherosclerosis than body mass index in the community-dwelling elderly?
Appendicular skeletal muscle mass index provides stronger and independent information on atherosclerosis risk compared to BMI in the elderly.
Answers are grounded in this paper and cite their sources.
Supports muscle mass assessment over BMI for atherosclerosis risk in elderly; hypothesis-generating and requires prospective validation.
AIMS: Low muscle mass is associated with advanced atherosclerosis. However, only very few studies on the elderly have investigated a dose-response relationship between muscle mass and atherosclerosis. Furthermore, whether the relationship between muscle mass and atherosclerosis is stronger than that between body mass index (BMI) and atherosclerosis among the elderly population remains to be determined. METHODS: ) or BMI. Using multivariable linear regression, we compared the slope of one standard deviation higher ASM index for baPWV with the corresponding slope of BMI, separately (single-index model) and jointly (simltaneously-adjusted model). RESULTS: The ASM index and BMI of a total of 995 participants (60.0% women, mean age 73 years) were significantly inversely associated with baPWV in a dose-response manner across the quintiles in both sexes. The slope for the ASM index tended to be greater than that for BMI in the single-index and simultaneously-adjusted models in both sexes after adjusting for confounders. CONCLUSIONS: Among a community-dwelling elderly population, the association between ASM and baPWV was stronger than, and independent of that between BMI and baPWV. These findings suggest that ASM provides more important information on atherosclerosis in the elderly than BMI does.
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Zhang et al. (2023) conducted a cross-sectional in Atherosclerosis (subclinical) (n=995). Appendicular skeletal muscle mass (ASM) index vs. Body mass index (BMI) was evaluated on Brachial-ankle pulse wave velocity (baPWV) (Slope -51 cm/s (men) and -48 cm/s (women) per 1 SD increase in ASM index (simultaneously-adjusted model), p=0.030 (men), 0.005 (women)). Higher appendicular skeletal muscle mass index was more strongly and independently associated with lower brachial-ankle pulse wave velocity than body mass index in community-dwelling older adults.
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