Key result
In dogs with one-vessel occlusion, intracoronary adenosine infusion decreased retrograde LAD flow from 3.2 to 2.4 ml/min (p<0.001), demonstrating coronary steal when other arteries are patent.
Why the study?
Does intracoronary adenosine infusion induce coronary steal in dogs with one-vessel occlusion and normally patent other arteries?
Population
10 dogs with occlusion of the left anterior descending coronary artery (LAD)
Comparison
Intracoronary adenosine infusion with constant… vs Baseline and varying levels of resistance
Design
Preclinical
Authors
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Adenosine may induce coronary steal despite single-vessel occlusion; animal findings extend mechanistic insight but leave human relevance open.
Does intracoronary adenosine infusion induce coronary steal in dogs with one-vessel occlusion and normally patent other arteries?
p-value: p=<0.001
Arteriolar vasodilators like adenosine can induce coronary steal even when only one artery is totally occluded and others are normally patent, due to native coronary resistance.
Patterson et al. (1983) studied Coronary occlusion (experimental) (n=10). Intracoronary adenosine infusion and graded partial stenosis vs. Baseline was evaluated on Retrograde LAD flow (p=<0.001). In dogs with one-vessel occlusion, intracoronary adenosine infusion decreased retrograde LAD flow from 3.2 to 2.4 ml/min (p<0.001), demonstrating coronary steal when other arteries are patent.
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