Key result
Treatment with 2% caprylic acid significantly lowered total cholesterol and LDL-C concentrations compared to control in mice with high fat diet-induced dyslipidemia (P < 0.05).
Why the study?
Do medium-chain fatty acids reduce serum cholesterol in a high-fat diet mouse model of dyslipidemia?
Do medium-chain fatty acids reduce serum cholesterol in a high-fat diet mouse model of dyslipidemia?
p-value: p=< 0.05
Medium-chain fatty acids, particularly caprylic acid, reduce serum cholesterol in hyperlipidemic mice by regulating bile acid metabolism.
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MCFAs may lower cholesterol in hyperlipidemic mice; leaves open human translation and efficacy trials.
Liu et al. (2016) studied Hypercholesterolemia (n=48). Medium-chain fatty acids (caprylic acid, capric acid, oleic acid) vs. Control group was evaluated on Concentrations of total cholesterol (TC) and LDL-C (p=< 0.05). Treatment with 2% caprylic acid significantly lowered total cholesterol and LDL-C concentrations compared to control in mice with high fat diet-induced dyslipidemia (P < 0.05).
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