What is the clinical evidence from this study?

Study design: Other. Population: Friend virus-induced acute erythroleukemia. Intervention: Friend virus strains (FV-A and FV-P).

January 1, 1980Cold Spring Harbor Symposia on Quantitative Biology

RNAs of Defective and Nondefective Components of Friend Anemia and Polycythemia Virus Strains Identified and Compared

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Key result

Friend virus strains FV-A and FV-P were identified as complexes consisting of defective components and helper Friend murine leukemia virus that induce acute erythroleukemia in susceptible mice.

Population

Susceptible mice (model for Friend virus-induced acute erythroleukemia)

Design

Preclinical

Authors

LELeonard H. EvansNational Institute of Allergy and Infectious Diseases MNMichael NunnSalk Institute for Biological Studies PDP H DuesbergUniversity of Southern California

Discussion

Member takes

Implication

Should not yet change clinical management of human leukemias; hypothesis-generating for retroviral pathogenesis in erythroleukemia.

Structured PICO

Population

Susceptible mice (model for Friend virus-induced acute erythroleukemia)

Exposure

Friend Anemia (FV-A) and Polycythemia (FV-P) Virus Strains

Outcome

Identification and comparison of RNAs of defective and nondefective components

Identifies the RNA components of Friend virus strains that induce anemia versus polycythemia in mice.

Cite This Study

Evans et al. (1980) studied Friend virus-induced acute erythroleukemia. Friend virus strains (FV-A and FV-P) was evaluated. Friend virus strains FV-A and FV-P were identified as complexes consisting of defective components and helper Friend murine leukemia virus that induce acute erythroleukemia in susceptible mice.

synapsesocial.com/papers/6a93b5eff74480727a463a77 https://doi.org/10.1101/sqb.1980.044.01.087

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