Key result
A 61-year-old woman with advanced liver angiosarcoma experienced rapid disease progression and died of intra-abdominal bleeding after receiving doxorubicin chemotherapy.
Why the study?
Hepatic angiosarcoma is a very rare malignancy that is more common in men, with only a few female cases reported to date.
Case Report (n=1)
No
Liver angiosarcoma is a rare, rapidly progressive malignancy with a poor prognosis that may present with severe complications such as intra-abdominal bleeding.
Highlights dismal prognosis of liver angiosarcoma; leaves open effective therapies for this rare malignancy.
Purpose: Hepatic angiosarcoma is very rare malignancy and more common in men than in women. To date, only a few female cases of liver angiosarcoma have been reported. Here, we report a female case of liver angiosarcoma, first detected in Vietnam, with a high malignancy stage, rapid progression, and poor prognosis. Case Presentation: A 61-year-old woman was admitted to the Bach Mai Hospital with fatigue, anorexia, weight loss, and severe pain in the right upper quadrant for 2 weeks prior. Clinical examination detected a firm 4-cm hepatomegaly below the right costal margin and grade I splenomegaly. Abdominal ultrasonography and CT revealed diffuse lesions in the entire liver parenchyma, spreading to the spleen, while MRI showed signs of bone metastasis. Blood tests showed elevated transaminase enzymes, especially Gamma Glutamyl Transferase 501 U/L; thrombocytopenia; no anemia; and other tumor markers such as AFP, CEA, and CA19-9 were within normal limits. On CT images, the dots and nodules in the liver and spleen appeared hyperenhanced in the arterial phase and washout in the venous phase. The results of both histopathology and immunohistochemistry showed liver angiosarcoma. Surgery and radiation were not indicated due to the suspicion of bone metastasis. Chemotherapy with doxorubicin at a dose of 60 mg/m2 and intravenous infusion once every 21 days was administered. Unfortunately, during the first dose of chemotherapy with doxorubicin, side effects appeared. Since the disease developed continuously and uncontrollably, the patient was subsequently exhausted, anemic, presented peritoneal fluid, and eventually died of intra-abdominal bleeding. Conclusion: For the diagnosis of liver angiosarcoma, ultrasound-guided liver biopsy could be applied for safe and effective histopathology, and selective embolization of the hepatic artery is necessary to prevent bleeding complications. The disease has a very poor prognosis, and if chemotherapy does not respond, the patient can die within six months of diagnosis.
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Hưng et al. (2022) conducted a case report in Liver angiosarcoma (n=1). Chemotherapy with doxorubicin was evaluated. A 61-year-old woman with advanced liver angiosarcoma experienced rapid disease progression and died of intra-abdominal bleeding after receiving doxorubicin chemotherapy.
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