Key result
A female patient with hepatic angiosarcoma developed cryptogenic cirrhosis, Kasabach-Merritt Syndrome, and bone marrow fibrosis as a result of her malignant lesions.
Why the study?
Hepatic angiosarcoma is a rare neoplasm with poor prognosis whose diagnosis is challenging due to vague presentations and early multiorgan dysfunction producing unique clinical syndromes.
Case Report (n=1)
Hepatic angiosarcoma is a rare neoplasm that can present with unique extrahepatic manifestations, requiring careful review of imaging enhancement patterns for diagnosis.
Raises awareness for atypical hepatic angiosarcoma presentations; extends known paraneoplastic associations but leaves open systematic validation.
Hepatic angiosarcoma is a rare and heterogeneous neoplasm that carries with it an especially poor prognosis. Diagnosis is challenging given that patients often present with vague, nonspecific complaints, and early multiorgan dysfunction has the potential to produce a number of unique clinical syndromes. Here, we present a case of a patient with hepatic angiosarcoma who developed cryptogenic cirrhosis, Kasabach-Merritt Syndrome (consumptive thrombocytopenia), and bone marrow fibrosis as a result of her malignant lesions. While parenchymal biopsy ultimately remains the gold standard for diagnosis, careful review of enhancement patterns on imaging may suggest malignant features in need of further investigation.
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Fields et al. (2020) conducted a case report in Hepatic angiosarcoma (n=1). A female patient with hepatic angiosarcoma developed cryptogenic cirrhosis, Kasabach-Merritt Syndrome, and bone marrow fibrosis as a result of her malignant lesions.
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