July 1, 2000Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Comparison of Anticoagulant Effects and Safety of Argatroban and Heparin in Healthy Subjects

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Why the study?

Does argatroban provide more predictable anticoagulation compared to heparin in healthy men?

Population

82 healthy men (aged 22-62 yrs) across three phase I studies.

Comparison

Argatroban. vs Heparin.

Design

RCT, Randomized, Double-blind, open-label

Authors

SSS. SwanCrystalGenomics (South Korea)JPJohn V. St. PeterUniversity of Minnesota LLLawrence J. LambrechtLuther University

Discussion

Member takes

Implication

Argatroban's predictable response and rapid offset may simplify periprocedural use; extends PK data from healthy volunteers to guide patient trials.

Structured PICO

Does argatroban provide more predictable anticoagulation compared to heparin in healthy men?

Population

82 healthy men (aged 22-62 yrs) across three phase I studies.

Intervention

Argatroban (ascending bolus doses 30-240 microg/kg, or infusion 1.25-40 microg/kg/minute with or without bolus).

Comparator

Heparin (bolus doses 15-240 U/kg, or infusion 0.15-0.30 U/kg/minute with or without bolus).

Outcome

Relationship between dosage and coagulation parameters (activated clotting time [ACT] and activated partial thromboplastin time [aPTT]) and safety profiles.surrogate

Argatroban provides more predictable dose-related anticoagulation with a faster offset of action compared to heparin in healthy subjects.

Cite This Study

Swan et al. (2000) studied this question.

synapsesocial.com/papers/6a93b91673075f1cdcafdeb5 https://doi.org/10.1592/phco.20.9.756.35194

Topics

Anticoagulation in AF

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Implication

Argatroban's predictable response and rapid offset may simplify periprocedural use; extends PK data from healthy volunteers to guide patient trials.

Comparison of Anticoagulant Effects and Safety of Argatroban and Heparin in Healthy Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Comparison of Anticoagulant Effects and Safety of Argatroban and Heparin in Healthy Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider