Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1990American Journal of Veterinary Research

Characterization of a panel of monoclonal antibodies and their use in the study of the antigenic diversity of bovine viral diarrhea virus

View Full Paper
Ask AI
Bookmark
Share

Key result

A panel of 40 monoclonal antibodies demonstrated that BVDV isolates have a high degree of antigenic variation largely confined to envelope glycoproteins associated with virus neutralization.

Population

Bovine viral diarrhea virus isolates, including the Singer strain and numerous field isolates of both…

Design

Preclinical

Authors

WCWayne V. CorapiTexas A&M UniversityRDRubén O. DonisCenters for Disease Control and PreventionEDEdward J. DuboviUniversity of Arkansas at Little Rock

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for BVDV vaccine strain selection; prospective bovine studies needed before practice impact.

Structured PICO

P
Population
Bovine viral diarrhea virus (BVDV) isolates, including the Singer strain and numerous field isolates of both cytopathic and noncytopathic biotypes
E
Exposure
A panel of 40 monoclonal antibodies (MAb) specific for BVDV
O
Outcome
Characterization of MAbs including viral protein specificity, immunoglobulin subclass, virus-neutralizing activity, and immunoreactivity with BVDV isolatessurrogate

BVDV exhibits significant antigenic variation primarily in envelope glycoproteins, which may impact disease development and severity.

Cite This Study

Corapi et al. (1990) studied Bovine viral diarrhea virus (BVDV). Monoclonal antibodies specific for BVDV was evaluated on Viral protein specificity, immunoglobulin subclass, virus-neutralizing activity, and immunoreactivity. A panel of 40 monoclonal antibodies demonstrated that BVDV isolates have a high degree of antigenic variation largely confined to envelope glycoproteins associated with virus neutralization.

synapsesocial.com/papers/6a93bd2e04450e732f7214b4https://doi.org/10.2460/ajvr.1990.51.09.1388
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenic Characterization of Bovine Viral Diarrhoea Virus Isolates from Spain with a Panel of Monoclonal Antibodies2000 · 9 citations
  2. 2Cell-protective monoclonal antibodies to bovine enterovirus-3 and partial or no activity against other serotypes1987 · 6 citations
  3. 3Production and diagnostic application of monoclonal antibodies against infectious bursal disease virus2011
  4. 4Production of Monoclonal Antibodies to Bovine Virus Diarrhoea Virus and their Reactivity with Selected Pestivirus Isolates1988 · 6 citations
  5. 5Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates2021 · 13 citations