June 30, 2015Journal of computational fluids engineeringOpen Access

Investigation on Mechanical and Bio-Mechanical Performance of a Centrifugal Blood Pump

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Rotaflow centrifugal blood pump vs. Different operational conditions (ECMO, VAD, full-load). Primary outcome: Modified index of hemolysis (MIH).

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Key result

Numerical simulations of the Rotaflow centrifugal blood pump revealed that the Ventricular Assist Device (VAD) condition had the lowest modified index of hemolysis (1170) compared to ECMO (7570) and full-load (9140) conditions.

Population

Computational model of the Rotaflow centrifugal blood pump

Comparison

Operation under ECMO, VAD, and full-load… vs Comparison between the different operational…

Design

Preclinical

Authors

MCMing‐Wei ChangUniversity of Ulster MMMohammad MoshfeghiSogang University NHNam‐lin HurUniversity of British Columbia

Discussion

Member takes

Implication

Simulations indicate lowest hemolysis under VAD conditions; leaves open clinical translation for Rotaflow pump use.

Structured PICO

Population

Computational model of the Rotaflow centrifugal blood pump

Intervention

Operation under ECMO (400 mmHg, 5 L/min), VAD (100 mmHg, 3 L/min), and full-load (600 mmHg, 10 L/min) conditions

Comparator

Comparison between the different operational conditions (ECMO, VAD, full-load)

Outcome

Mechanical performance (performance curves) and bio-mechanical performance (hemolytic characteristics, modified index of hemolysis [MIH])surrogate

Numerical simulations of the Rotaflow centrifugal blood pump indicate that hemolysis risk is lowest under VAD conditions and highest under full-load conditions.

Limitations

Steady-state condition assumed, eliminating time dependency of flow parameters
Standard k-epsilon model assumes isotropic turbulence
Von Mises stresses calculated solely based on laminar stress values

Cite This Study

Chang et al. (2015) studied this question. Rotaflow centrifugal blood pump vs. Different operational conditions (ECMO, VAD, full-load) was evaluated on Modified index of hemolysis (MIH). Numerical simulations of the Rotaflow centrifugal blood pump revealed that the Ventricular Assist Device (VAD) condition had the lowest modified index of hemolysis (1170) compared to ECMO (7570) and full-load (9140) conditions.

synapsesocial.com/papers/6a93bd58ec4af56311ebc3fe https://doi.org/10.6112/kscfe.2015.20.2.088

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Investigation on Mechanical and Bio-Mechanical Performance of a Centrifugal Blood Pump

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Investigation on Mechanical and Bio-Mechanical Performance of a Centrifugal Blood Pump

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider