Key result
In patients with sepsis or septic shock, 3D left ventricular global longitudinal strain was significantly reduced on day 1 compared to healthy controls (-15.3% vs -22.2%, p<0.01), worsened by day 3, and partially recovered by days 7-10.
Why the study?
This study aimed to investigate the serial changes in left ventricular myocardial deformation in patients with sepsis using 3D and 2D speckle tracking echocardiography.
Does serial assessment with 3D and 2D speckle tracking echocardiography detect changes in left ventricular myocardial deformation in patients with sepsis or septic shock?
Population
59 ICU patients with sepsis or septic shock and 40 healthy controls
Comparison
Patients with sepsis or septic shock vs healthy controls
Design
Single-center prospective observational study
Follow-up
Seventh to the tenth day
Authors
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May reflect reversible myocardial dysfunction in sepsis; leaves open whether serial 3D strain aids risk stratification.
Observational (n=99)
No
Does serial assessment with 3D and 2D speckle tracking echocardiography detect changes in left ventricular myocardial deformation in patients with sepsis or septic shock?
Absolute Event Rate: -15.3% vs -22.2%
p-value: p=<0.01
3D and 2D speckle tracking echocardiography can effectively monitor the evolution and gradual, incomplete recovery of myocardial deformation in patients with sepsis or septic shock over a 10-day period.
Yan et al. (2022) conducted an observational in Sepsis or septic shock (n=99). Sepsis or septic shock vs. Healthy controls was evaluated on 3D left ventricular global longitudinal strain (LVGLS) on the first day (p=<0.01). In patients with sepsis or septic shock, 3D left ventricular global longitudinal strain was significantly reduced on day 1 compared to healthy controls (-15.3% vs -22.2%, p<0.01), worsened by day 3, and partially recovered by days 7-10.
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