Key result
Depressive symptoms at discharge from a cardiac rehabilitation program significantly predicted future cardiovascular-related hospitalizations (HR 1.32; 95% CI 1.09-1.60; p=0.004).
Why the study?
Do depressive symptoms at discharge from cardiac rehabilitation predict future CVD-related hospitalizations in patients with cardiovascular disease?
Cohort (n=486)
Do depressive symptoms at discharge from cardiac rehabilitation predict future CVD-related hospitalizations in patients with cardiovascular disease?
Hazard Ratio: 1.32 (95% CI 1.09–1.6)
p-value: p=0.004
Clinically relevant depressive symptoms at discharge from cardiac rehabilitation are associated with a significantly increased risk of future CVD-related hospitalizations.
Supports monitoring depressive symptoms at cardiac rehab discharge; leaves open whether intervention reduces hospitalizations.
OBJECTIVES: Depression is associated with poor prognosis in patients with cardiovascular disease (CVD). We hypothesized that depressive symptoms at discharge from a cardiac rehabilitation program are associated with an increased risk of future CVD-related hospitalizations. METHODS: We examined 486 CVD patients (mean age=59.8±11.2) who enrolled in a comprehensive 3-month rehabilitation program and completed the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D). At follow-up we evaluated the predictive value of depressive symptoms for CVD-related hospitalizations, controlling for sociodemographic factors, cardiovascular risk factors, and disease severity. RESULTS: During a mean follow-up of 41.5±15.6 months, 63 patients experienced a CVD-related hospitalization. The percentage of depressive patients (HADS-D≥8) decreased from 16.9% at rehabilitation entry to 10.7% at discharge. Depressive symptoms at discharge from rehabilitation were a significant predictor of outcome (HR 1.32, 95% CI 1.09-1.60; p=0.004). Patients with clinically relevant depressive symptoms at discharge had a 2.5-fold increased relative risk of poor cardiac prognosis compared to patients without clinically relevant depressive symptoms independently of other prognostic variables. CONCLUSION: In patients with CVD, depressive symptoms at discharge from rehabilitation indicated a poor cardiac prognosis.
No takes yet. Share an insight, caveat, or question.
Meyer et al. (2015) conducted a cohort in Cardiovascular disease (n=486). Depressive symptoms at discharge vs. No clinically relevant depressive symptoms at discharge was evaluated on CVD-related hospitalizations (HR 1.32, 95% CI 1.09-1.60, p=0.004). Depressive symptoms at discharge from a cardiac rehabilitation program significantly predicted future cardiovascular-related hospitalizations (HR 1.32; 95% CI 1.09-1.60; p=0.004).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: