Key result
Exposure to TCAs (e.g., dothiepin OR 1.90; 95% CI 1.15-3.14) and SSRIs was associated with an increased risk of MI, though likely confounded by underlying depression.
Why the study?
Do tricyclic antidepressants and selective serotonin reuptake inhibitors increase the risk of first acute myocardial infarction in the general population?
Population
Over 60,000 cases of MI and 360,000 age, sex, and practice matched controls randomly selected from the UK…
Comparison
Tricyclic antidepressants and selective… vs Age, sex, and practice matched controls and…
Design
Case-control
Authors
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Association likely confounded by depression; should not change prescribing and leaves open any causal MI risk.
Case-Control (n=420,000)
Yes
Do tricyclic antidepressants and selective serotonin reuptake inhibitors increase the risk of first acute myocardial infarction in the general population?
Odds Ratio: 1.9 (95% CI 1.15–3.14)
While initial prescriptions of TCAs and SSRIs are associated with an increased risk of MI, this association is likely confounded by underlying depression and healthcare utilization rather than representing a direct adverse drug effect.
Laila J. Tata (2005) conducted a case-control in Acute myocardial infarction (n=420,000). Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) vs. Matched controls was evaluated on First acute myocardial infarction (OR 1.90, 95% CI 1.15-3.14). Exposure to TCAs (e.g., dothiepin OR 1.90; 95% CI 1.15-3.14) and SSRIs was associated with an increased risk of MI, though likely confounded by underlying depression.
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