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March 1, 1992Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine

A Model of the Geometrical Changes in Aortic Valve Leaflets in Response to Leaflet Extension and Variable Boundary Conditions

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Key result

A mathematical model demonstrated that both the angle of inclination and the radius of curvature of a cylindrical leaflet were reduced with increased leaflet length or decreased aortic diameter.

Population

Mathematical model of a cylindrical leaflet and experimental observations in porcine bioprosthetic heart…

Design

Preclinical

Authors

JFJohn FisherMBM.H. ButterfieldKLK.J. Lockie

Discussion

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Overview

May inform bioprosthetic leaflet design parameters; leaves open validation in clinical implants.

Structured PICO

P
Population
Mathematical model of a cylindrical leaflet and experimental observations in porcine bioprosthetic heart valves
E
Exposure
Variation of aortic root diameter (boundary conditions) and leaflet length (permanent extension)
O
Outcome
Geometrical changes in the leaflet (angle of inclination and radius of curvature)surrogate

A mathematical model successfully predicts geometrical changes in aortic valve leaflets under varying boundary conditions, which may help optimize the design and preparation of bioprosthetic heart valves.

Cite This Study

Fisher et al. (1992) studied Abnormal geometry and function in heart valve leaflets. Mathematical model of cylindrical leaflet geometry was evaluated on Changes in geometry of a cylindrical leaflet (angle of inclination and radius of curvature). A mathematical model demonstrated that both the angle of inclination and the radius of curvature of a cylindrical leaflet were reduced with increased leaflet length or decreased aortic diameter.

synapsesocial.com/papers/6a93be9940aff459acebcb03https://doi.org/10.1243/pime_proc_1992_206_256_02
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leaflet geometry and function in porcine bioprostheses1991 · 16 citations
  2. 2Failure and Hydrodynamic Function Testing of Explanted Pericardial and Porcine Bioprosthetic Valves1989 · 12 citations
  3. 3Hydrodynamic Function of Second Generation Porcine Bioprosthetic Heart Valves1991 · 18 citations
  4. 4Influence of fixation conditions on the performance of glutaraldehyde-treated porcine aortic valves: towards a more scientific basis.1979 · 118 citations