Key result
Perioperative fentanyl equivalents >28.7μg/kg was associated with a significantly increased risk of postoperative complications (OR 2.800) in elderly patients with non-small cell lung cancer.
Why the study?
With an aging population and increasing lung cancer cases among the elderly, this study aimed to explore the association between perioperative factors and short-term outcomes in elderly patients with NSCLC.
Cohort (n=490)
No
Perioperative factors including fentanyl dose, surgery duration, and intraoperative blood loss are independent predictors of short-term outcomes in elderly patients undergoing surgery for non-small cell lung cancer.
Background: People in China have gradually entered old age society, and the number of lung cancer cases is expected to increase annually among the elderly. This study aimed to retrospectively explore the association between perioperative factors and short-term outcomes in elderly patients with non-small cell lung cancer (NSCLC). Methods: A total of 490 elderly patients with NSCLC between January 1, 2003, and December 31, 2009, were selected. Perioperative factors were grouped and analyzed according to postoperative complications (PPCs) and length of hospital stay. A logistic regression analysis model was used to screen for the independent predictors of patient prognosis. The primary endpoint was postoperative complications and the secondary endpoint was postoperative hospital stay. Results: Of all patients, 344 (70.2%) developed postoperative complications, and the average length of stay after surgery was 14.0±5.6 days. Perioperative fentanyl equivalents>28.7μg/kg and duration of surgery>4.4h were associated were associated with an increased risk of postoperative complications (P < 0.05); intraoperative blood loss (IBL) > 200 mL was associated with extended hospital stay (P < 0.05). Conclusion: This study suggested that Perioperative factors may affect the short-term prognosis of elderly NSCLC patients after surgery. Perioperative fentanyl equivalents>28.7μg/kg, surgery duration, and IBL may be independent predictors of short-term outcomes in elderly patients.
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Zhu et al. (2024) conducted a cohort in Non-Small Cell Lung Cancer (NSCLC) (n=490). Perioperative fentanyl equivalents >28.7μg/kg vs. Perioperative fentanyl equivalents ≤28.7μg/kg was evaluated on Postoperative complications (OR 2.800, 95% CI 1.759-4.456, p=<0.001). Perioperative fentanyl equivalents >28.7μg/kg was associated with a significantly increased risk of postoperative complications (OR 2.800) in elderly patients with non-small cell lung cancer.
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