Key result
Opioid-less perioperative care and multimodal analgesia strategies are warranted to mitigate adverse events, opioid-induced hyperalgesia, and diversion associated with indiscriminate opioid use.
Highlights the need for multimodal analgesia strategies to reduce opioid-related adverse events in perioperative care.
Multimodal analgesia may curb perioperative opioid harms; leaves open optimal regimens for prospective trials.
Opioids are the most frequently administered analgesics in the perioperative period. The analgesic potency of opioids is without question. While the opioid- free or opioid-less perioperative care concept is not a reality in most surgical centers of the United States and other developed countries, there is a significant number of healthcare problems (i.e. adverse events, opioid-induced hyperalgesia and opioid diversion) related to the indiscriminate use of opioids that warrants the implementation of multimodal analgesia strategies. Although it has been suggested an association between the use of opioids and cancer progression, there is a need of well-designed studies to confirm that association.
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Cata et al. (2017) conducted a review in Perioperative pain. Opioid-less perioperative care was evaluated. Opioid-less perioperative care and multimodal analgesia strategies are warranted to mitigate adverse events, opioid-induced hyperalgesia, and diversion associated with indiscriminate opioid use.
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