Key result
Women with third-trimester unexplained intrauterine fetal death had a significantly higher prevalence of inherited thrombophilias compared to healthy controls (42.5% vs 15%; OR 2.8, 95% CI 1.5-5.3, P=0.001).
Why the study?
Are inherited thrombophilias associated with an increased risk of third-trimester unexplained intrauterine fetal death?
Population
120 women, comprising 40 women with unexplained intrauterine fetal death at ≥27 weeks' gestation and 80…
Comparison
Presence of inherited thrombophilias vs Healthy women with at least one normal pregnancy
Design
Case-control
Authors
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Inherited thrombophilias were associated with third-trimester IUFD; observational data leave screening benefit and causality open.
Case-Control (n=120)
Are inherited thrombophilias associated with an increased risk of third-trimester unexplained intrauterine fetal death?
Odds Ratio: 2.8 (95% CI 1.5–5.3)
Absolute Event Rate: 42.5% vs 15%
p-value: p=.001
Inherited thrombophilias are significantly associated with third-trimester unexplained intrauterine fetal death, suggesting that thrombophilia screening should be included in IUFD investigations.
Ariel Many (2002) conducted a case-control in Unexplained intrauterine fetal death (IUFD) (n=120). Unexplained intrauterine fetal death (IUFD) vs. Healthy women with at least one normal pregnancy was evaluated on Inherited thrombophilias (OR 2.8, 95% CI 1.5-5.3, p=.001). Women with third-trimester unexplained intrauterine fetal death had a significantly higher prevalence of inherited thrombophilias compared to healthy controls (42.5% vs 15%; OR 2.8, 95% CI 1.5-5.3, P=0.001).
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