Key result
Pulsed cardiopulmonary bypass using an intra-aortic balloon pump improved the flow pattern directed towards the epiaortic vessels with a mean flow increase of 6.3% and reduced flow vorticity.
Why the study?
Does pulsed cardiopulmonary bypass with IABP improve blood flow to epiaortic vessels compared to standard CPB in a computational model?
Does pulsed cardiopulmonary bypass with IABP improve blood flow to epiaortic vessels compared to standard CPB in a computational model?
Effect estimate: mean flow increase of 6.3%
Computational modeling suggests that pulsed cardiopulmonary bypass using an IABP may improve blood flow to epiaortic vessels and reduce flow vorticity, potentially mitigating stroke risk during cardiac surgery.
Hypothesis-generating for stroke risk reduction in cardiac surgery; leaves open need for clinical validation of pulsed CPB with IABP.
In the modern era, stroke remains a main cause of morbidity after cardiac surgery despite continuing improvements in the cardiopulmonary bypass (CPB) techniques. The aim of the current work was to numerically investigate the blood flow in aorta and epiaortic vessels during standard and pulsed CPB, obtained with the intra-aortic balloon pump (IABP). A multi-scale model, realized coupling a 3D computational fluid dynamics study with a 0D model, was developed and validated with in vivo data. The presence of IABP improved the flow pattern directed towards the epiaortic vessels with a mean flow increase of 6.3% and reduced flow vorticity.
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Gramigna et al. (2014) studied Cardiac surgery requiring cardiopulmonary bypass. Pulsed cardiopulmonary bypass with intra-aortic balloon pump (IABP) vs. Standard cardiopulmonary bypass was evaluated on Blood flow in aorta and epiaortic vessels (mean flow increase of 6.3%). Pulsed cardiopulmonary bypass using an intra-aortic balloon pump improved the flow pattern directed towards the epiaortic vessels with a mean flow increase of 6.3% and reduced flow vorticity.
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