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January 7, 1999New England Journal of MedicineOpen Access

Increased Frequency of Genetic Thrombophilia in Women with Complications of Pregnancy

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Why the study?

Is genetic thrombophilia associated with an increased risk of serious obstetrical complications in pregnant women?

Population

220 women, comprising 110 women with serious obstetrical complications and 110 women with one or more normal…

Design

Case-control

Authors

MKMichael J. KupfermincNorthwestern UniversityAEAmiram EldorUniversité Claude Bernard Lyon 1NSNitzan SteinmanTel Aviv University

Discussion

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Overview

Thrombophilia was associated with obstetrical complications; leaves open whether screening or treatment improves outcomes.

Structured PICO

Is genetic thrombophilia associated with an increased risk of serious obstetrical complications in pregnant women?

P
Population
220 women, comprising 110 women with serious obstetrical complications (severe preeclampsia, abruptio placentae, fetal growth retardation, and stillbirth) and 110 women with one or more normal pregnancies.
C
Comparator
Women with normal pregnancies.
O
Outcome
Frequency of thrombophilic mutations (factor V Leiden, MTHFR C677T, prothrombin G20210A) and deficiencies of protein C, protein S, antithrombin III, or presence of anticardiolipin antibodies.surrogate

Women with serious obstetrical complications have a significantly higher incidence of inherited and acquired forms of thrombophilia compared to women with normal pregnancies.

Cite This Study

Kupferminc et al. (1999) studied this question.

synapsesocial.com/papers/6a93bf3792179ea5e4b853bdhttps://doi.org/10.1056/nejm199901073400102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies1997 · 204 citations
  2. 2A Common Prothrombin Variant (20210 G to A) Increases the Risk of Myocardial Infarction in Young Women1997 · 358 citations
  3. 3A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  4. 4Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk1998 · 672 citations
  5. 5Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia1997 · 226 citations