Key result
In vivo testing of an electrohydraulic actuated total artificial heart in 4 calves demonstrated pump outputs of 4.0-9.5 L/min at left atrial pressures of 7-16 mmHg, suggesting potential for clinical use.
Why the study?
Does an electrohydraulic actuated total artificial heart provide stable hemodynamics in a calf model?
Population
n=4 calves with preoperative body weights of 84, 94, 82, and 82 kg
Design
Preclinical
Follow-up
1, 5, 9, and 45 days
Authors
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Does not support clinical use; leaves open need for durability and long-term animal studies before translation.
Does an electrohydraulic actuated total artificial heart provide stable hemodynamics in a calf model?
Initial in vivo testing of an electrohydraulic actuated total artificial heart in calves demonstrated stable hemodynamics, suggesting potential for total implantable cardiac replacement.
IRIÉ et al. (1992) studied Total artificial heart replacement (in vivo testing) (n=4). Electrohydraulic actuated total artificial heart (TAH) was evaluated on Hemodynamic performance (pump output, left atrial pressures, pump rates). In vivo testing of an electrohydraulic actuated total artificial heart in 4 calves demonstrated pump outputs of 4.0-9.5 L/min at left atrial pressures of 7-16 mmHg, suggesting potential for clinical use.
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