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A purified 7S-gamma globulin fraction of a rabbit anti-human lymphocyte serum (RAHLS) has been prepared. This material agglutinates and kills human lymph node cells and peripheral blood lymphocytes in vitro. Human subjects given 7S-RAHLS show transient lymphopenia associated with moderately prolonged abolition of positive delayed skin reactions and modest prolongation of skin allograft survival.
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Monaco et al. (1967) studied this question.
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