Key result
Bicuspid aortic valve aortopathy manifests as aortic root aneurysm or tubular ascending aortic dilation, driven by a combination of genetic variants and altered hemodynamic forces.
Population
Patients with bicuspid aortic valve (BAV) and ascending aortic dilation (AAD)
Design
Review
Authors
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Supports distinct genetic-hemodynamic mechanisms in BAV aortopathy phenotypes; leaves open targeted interventions for prospective validation.
This review proposes distinct pathogenic mechanisms for different phenotypes of bicuspid aortic valve aortopathy, suggesting genetic drivers for aortic root aneurysms and hemodynamic drivers for tubular ascending aortic dilation.
Yassine et al. (2017) conducted a review in Bicuspid Aortic Valve Aortopathy. Bicuspid aortic valve aortopathy manifests as aortic root aneurysm or tubular ascending aortic dilation, driven by a combination of genetic variants and altered hemodynamic forces.
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