Key result
Factor V-Leiden and prothrombin G20210A mutations were more prevalent in women with recurrent miscarriages (40.91% and 13.64%, respectively) compared to controls (16.42% and 2.99%).
Why the study?
Are factor V G1691A and prothrombin G20210A mutations associated with recurrent idiopathic miscarriages?
Case-Control (n=177)
Are factor V G1691A and prothrombin G20210A mutations associated with recurrent idiopathic miscarriages?
Absolute Event Rate: 40.91% vs 16.42%
Factor V-Leiden and prothrombin G20210A mutations are significantly more prevalent in women with recurrent idiopathic miscarriages, suggesting they are major inherited risk factors.
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Supports association of these mutations with recurrent miscarriages; leaves open whether screening or therapy alters outcomes.
Finan et al. (2002) conducted a case-control in Recurrent idiopathic miscarriages (n=177). Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations vs. Parous women with uncomplicated pregnancies was evaluated on Prevalence of FV-Leiden mutation. Factor V-Leiden and prothrombin G20210A mutations were more prevalent in women with recurrent miscarriages (40.91% and 13.64%, respectively) compared to controls (16.42% and 2.99%).
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