Key result
The combination of an abnormal trimester-specific D-dimer level and modified Wells score was present in 100% of pregnant patients with pulmonary embolism compared to 26.2% without PE (p=0.001).
Why the study?
Does the combination of trimester-specific D-dimer levels and modified Wells score accurately exclude pulmonary embolism in pregnant women?
Cohort (n=59)
Does the combination of trimester-specific D-dimer levels and modified Wells score accurately exclude pulmonary embolism in pregnant women?
Absolute Event Rate: 100% vs 26.2%
p-value: p=0.001
The combination of trimester-specific D-dimer levels and the modified Wells score may safely triage pregnant women with suspected PE to a low-risk category, potentially avoiding unnecessary radiation exposure from diagnostic imaging.
No takes yet. Share an insight, caveat, or question.
May support low-risk triage for suspected PE in pregnancy; hypothesis-generating and requires prospective validation before adoption.
Fournogerakis et al. (2016) conducted a cohort in Suspected pulmonary embolism in pregnancy (n=59). Documented pulmonary embolism vs. No documented pulmonary embolism was evaluated on Abnormal combination of trimester-specific D-dimer level and modified Wells score (p=0.001). The combination of an abnormal trimester-specific D-dimer level and modified Wells score was present in 100% of pregnant patients with pulmonary embolism compared to 26.2% without PE (p=0.001).
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