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Inoculation of humans with live human cancer extracts may lead to the establishment of progressively growing tumors in the recipients and cause dissemination of a fatal disease. Close relatives are particularly susceptible to the inoculation of tumors from genetically related donors. The results of inoculation of cancer extracts from human patients to unrelated human recipients are unpredictable. In rare instances, the implanted tumors may “take,” grow progressively, and lead to a generalization of the disease. Administration of immunosuppressive drugs, such as azathioprine or prednisone, lowers natural resistance of the host to heterologous tumors; patients receiving such treatment are particularly susceptible to transmission of human cancer.
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Ludwik Gross (1971) studied this question.
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