Cervical dysplasia and cancer developing in women on immunosuppression therapy for renal homotransplantation

A study of cervical changes has been made of 28 female patients over the age of 11 years who have received renal transplants for end-stage kidney disease. Three of these patients have shown cellular abnormalities on Papanicolaou smears. One patient showed mild dysplasia in only one smearbut the other 2 have shown persistent atypicalities and one of the 2 developed in-situ epithelioma proven by cervical conization. While definite proof that the cervical changes are due to immunosuppressive therapy is lackinga plea is made to subject all transplanted patients to routine cervical smears and to record all features of dysplasia and frank malignancy in order that proper assessment of their significance may be made in the future.