Prevention of Postprandial Hypotension with Somatostatin

Brief Reports1 December 1985Prevention of Postprandial Hypotension with SomatostatinROBERT D. HOELDTKE, M.D., Ph.D., THOMAS M. O'DORISIO, M.D., GUENTHER BODEN, M.D.ROBERT D. HOELDTKE, M.D., Ph.D., THOMAS M. O'DORISIO, M.D., GUENTHER BODEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-889 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with autonomic neuropathy may develop profound hypotension after eating (1, 2). We have recently seen a patient whose mean blood pressure fell 60 to 80 mm Hg each day after breakfast. We were unable to prevent his postprandial hypotension with fludrocortisone, indomethacin, or dihydroergotamine. Pretreatment with intravenous somatostatin, however, prevented the postprandial decrease in blood pressure.A 70-year-old white man had chronic alcoholism, autonomic neuropathy, hypoaldosteronism, esophageal stricture, and recurrent gastritis. He had dizziness and blurred vision on standing upright or after a meal. His blood pressure was 150/70 mm Hg when supine and 65/35 mm Hg when upright....References1. SEYER-HANSEN K. Postprandial hypotension. Br Med J. 1977;2:1262. CrossrefMedlineGoogle Scholar2. ROBERTSONWADEROBERTSON DDR. Postprandial alterations in cardiovascular hemodynamics in autonomic dysfunction states. Am J Cardiol. 1981;48:1048-52. CrossrefMedlineGoogle Scholar3. EWINGCAMPBELLCLARKE DIB. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med. 1980;92(2 pt 2):308-11. LinkGoogle Scholar4. MATONO'DORISIOHOWE PTB. Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera. N Engl J Med. 1985;312:17-21. CrossrefMedlineGoogle Scholar5. SOELDERSSLONE JD. Critical variables in the radioimmunoassay of serum insulin using the double antibody technique. Diabetes. 1965;14:771-6. CrossrefMedlineGoogle Scholar6. BODENSIVITZOWEN GMO. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science. 1975;190:163-5. CrossrefMedlineGoogle Scholar7. REICHLIN S. Somatostatin. N Engl J Med. 1983;25:1556-64. CrossrefGoogle Scholar8. LIPSITZNYQUISTWEIROWE LRJJ. Postprandial reduction of blood pressure in the elderly. N Engl J Med. 1983;309:81-3. CrossrefMedlineGoogle Scholar9. ADRIANGREENBERGBLOOM TGS. Actions of pancreatic polypeptide in man. In: BLOOM SR, POLAK JM, eds. Gut Hormones. New York: Churchill Livingstone; 1981:206-12. Google Scholar10. SCHUSDZIARRAZYZNARROUILLER VED. Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis. Science. 1980;207:530-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Temple University School of Medicine Philadelphia, Pennsylvania the Ohio State University Hospital Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of the Autonomic Nervous SystemEffects of intraduodenal glucose, fat, and protein on blood pressure, heart rate, and splanchnic blood flow in healthy older subjectsThe hypotensive response to oral fat is comparable but slower compared with carbohydrate in healthy elderly subjectsManagement of Autonomic FailureRelationship of age and calcitonin gene-related peptide to postprandial hypotensionCardiovascular effects of eating, atenolol and their interaction: β1-adrenergic modulation does not play a predominant role in the genesis of postprandial effectsHormonal Mechanisms of Postprandial HypotensionPostprandial hypotension. Pathophysiological mechanisms and clinical implications in different disorders.Hemodynamic effects of octreotide in patients with autonomic neuropathy.The effect of oral glucose, protein, fat and water loading on blood pressure and the gastrointestinal peptides VIP and somatostatin in hypertensive elderly subjectsInfluence of Octreotide (SMS 201-995) and Insulin Administration on the Course of Blood Pressure After an Oral Glucose Load in Hypertensive Elderly SubjectsPrandial effects on cardiac function and responsesTherapy of the Malignant Carcinoid SyndromeTherapy of the Malignant Carcinoid Syndrome and Metastatic Islet Cell CarcinomaTherapeutic Considerations for the Malignant Carcinoid SyndromeEndocrinology in agingNew Issues in Geriatric CareDAVID H. SOLOMON, M.D., HOWARD L. JUDD, M.D., HERBERT C. SIER, M.D., LAURENCE Z. RUBENSTEIN, M.D., JOHN E. MORLEY, M.D.Treatment of diabetic diarrhea and orthostatic hypotension with somatostatin analogue SMS 201–995Hemodynamic Changes During Food Ingestion in a Patient With Postprandial HypotensionTreatment of postprandial hypotension with a somatostatin analogue (SMS 201-995)Postprandial alterations in hemodynamics and blood pressure in normal subjectsTREATMENT OF AUTONOMIC NEUROPATHY WITH A SOMATOSTATIN ANALOGUE SMS-201-995Treatment of Orthostatic Hypotension with Dihydroergotamine and CaffeineROBERT D. HOELDTKE, M.D., Ph.D., STEPHEN T. CAVANAUGH, B.A., JOHN D. HUGHES, B.A., MARCIA POLANSKY, Sc.D. 1 December 1985Volume 103, Issue 6_Part_1Page: 889-890KeywordsAlcoholismBlood pressureEatingFludrocortisoneGastritisHypotensionNeuropathySomatostatinVision Issue Published: 1 December 1985 Copyright©1985 American College of PhysiciansPDF DownloadLoading ...