Blood serum specimens from patients with rheumatoid arthritis who had never received chrysotherapy, patients with rheumatoid arthritis who had been receiving chrysotherapy for a period of 18 months or more and normal volunteers were analyzed by emission spectroscopy for eight trace elements. Compared with the normal volunteers, the mean concentrations of copper, molybdenum, manganese, tin, barium and cesium were elevated in blood serum from patients with rheumatoid arthritis who had never received chrysotherapy. Chrysotherapy resulted in a decrease in molybdenum, manganese, tin, barium and cesium. The mean concentrations (compared with the normal) of zinc and iron were lower in blood serum of patients with rheumatoid arthritis who had never received gold therapy. Chrysotherapy had no apparent effect on iron or zinc.
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Niedermeier et al. (1971) studied this question.
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