Key result
Higher GD3 synthase activity in rat liver homogenates correlated with higher proportions of b-series gangliosides, with older males expressing five-fold higher activity than females.
Animal data do not inform clinical practice; leaves open whether sex- and age-specific GD3 synthase regulation translates to humans.
Variations of the ganglioside composition in the livers of Wistar rats correlated with the activity of GD3 synthase in the corresponding liver homogenates. With increasing enzyme activity, higher proportions of b-series gangliosides (GD3, GD1b, GT1b) were detected. No significant changes in the activity of GM2 synthase or GM1 synthase were observed, indicating a regulatory function for GD3 synthase in this tissue. Young animals showed an average GD3 synthase activity of 0.5-0.6 nmol.h-1.mg protein-1 without sex-dependent variations. Among the older animals, however, males expressed an activity five-fold higher than females, suggesting that this enzyme might be affected by hormones.
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Schüz-Henninger et al. (1989) studied this question. GD3 synthase activity was evaluated on Ganglioside composition (GD3, GD1b, GT1b). Higher GD3 synthase activity in rat liver homogenates correlated with higher proportions of b-series gangliosides, with older males expressing five-fold higher activity than females.
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