In Vitro Analysis of Platelet Function During Storage of Platelets from Plasmapheresed Donors

Several in vitro platelet function assays were examined. Two units of platelets from each of ten volunteer donors were obtained by plasmapheresis, stored three days, and examined by various functional parameters. The second unit of platelets from an individual had generally lower functional parameters than the first, suggesting a subtle physiological change in the donors' circulation between the time of drawing the first and second units. For in vitro comparisons, this difference was overcome by a pooling procedure. Platelet storage was examined at room temperature and at 4 C.