Key result
Width-weighted sizing is linked to ~28% higher WEB device compression vs standard IFU sizing.
Why the study?
The Woven EndoBridge device is sensitive to sizing; a novel width-weighted method was developed to increase neck compression and flow disruption, but its clinical and angiographic impacts needed evaluation.
Does the width weighted method for WEB device sizing improve device compression and occlusion rates compared to the standard IFU method in patients with cerebral aneurysms?
Cohort (n=68)
No
Does the width weighted method for WEB device sizing improve device compression and occlusion rates compared to the standard IFU method in patients with cerebral aneurysms?
Absolute Event Rate: 41% vs 32%
p-value: p=<.05
The width-weighted sizing method for the Woven EndoBridge device improves device compression compared to standard sizing, potentially leading to better occlusion rates without increasing complications.
BACKGROUND AND OBJECTIVES: The Woven EndoBridge (WEB) device, developed for wide neck bifurcation aneurysms, is sensitive to appropriate sizing. The instructions for use (IFU) sizing method is based on aneurysm width and dome height. In our institution, we developed a method emphasizing width dimensions to guide WEB selection (width weighted method, WWM) to increase device compression at the neck and consequently flow disruption. We sought to explore the impact of the WWM on WEB compression, angiographic flow disruption, and occlusion rates. METHODS: Consecutive patients with cerebral aneurysms with at least 1 year of follow-up (from February 2019 to December 2023), treated with WEB using the standard IFU sizing method vs the WWM method, were included. Clinical, angiographic, and geometric data were collected and analyzed. RESULTS: A total of 68 aneurysms were included (10 ruptured, 58 unruptured). WEB deployment was technically successful in 67 of 68 aneurysms (98.5%), with complications occurring in 2 patients (2.9%). WWM led to increasing device width dimensions in 35 of 68 cases (51%) with low resizing (2/68, 2.8%) rates. Device compression measured based on WWM was higher compared with theoretical compression based on IFU (41% vs 32%, P < .05). Adequate occlusion (web occlusion scale score 0-2) was achieved in 64 of 68 aneurysms (94.1%) at 1-year follow-up. CONCLUSION: WWM is a structured technique that can lead consistent selection of wider devices to better device compression compared with the IFU-based method. This technique may offer safe and superior flow disruption without an increase in complication rate, potentially translating to higher occlusion rates.
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Doron et al. (2025) conducted a cohort in cerebral aneurysms (n=68). Width-weighted method (WWM) for WEB sizing vs. Standard instructions for use (IFU) sizing method was evaluated on Device compression (p=<.05). The width-weighted sizing method for Woven EndoBridge devices resulted in higher device compression compared with the standard IFU method (41% vs 32%, P < .05).
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