Key result
Dex40-GTMAC3 was rapidly eliminated with a half-life of 12.5 minutes and was well tolerated without causing blood or organ toxicity, whereas protamine caused permanent liver and kidney damage.
Why the study?
Does Dex40-GTMAC3 have a favorable toxicokinetic and safety profile for the reversal of unfractionated heparin in animal models?
Population
Mice and Wistar rats
Comparison
Dex40-GTMAC3 vs Protamine sulfate
Design
Preclinical
Authors
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May support Dex40-GTMAC3 development for heparin reversal; hypothesis-generating and requires human trials.
Does Dex40-GTMAC3 have a favorable toxicokinetic and safety profile for the reversal of unfractionated heparin in animal models?
Dex40-GTMAC3 demonstrates a favorable toxicokinetic and safety profile in rodents, suggesting it is a promising, biocompatible candidate for unfractionated heparin reversal.
Sokołowska et al. (2016) studied Unfractionated heparin reversal (n=76). Dex40-GTMAC3 vs. Protamine sulfate or Vehicle (PBS) was evaluated on Terminal elimination half-life (T1/2) and organ toxicity. Dex40-GTMAC3 was rapidly eliminated with a half-life of 12.5 minutes and was well tolerated without causing blood or organ toxicity, whereas protamine caused permanent liver and kidney damage.
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