Key result
PAH-ARG polymers effectively neutralized heparin and reversed aPTT to normal levels in vitro and in a rat model, requiring half the dose of protamine sulfate.
Why the study?
Does PAH-ARG reverse heparin-induced aPTT prolongation more effectively than protamine sulfate in preclinical models?
Population
In vitro heparinized blood plasma, in vivo rat model, and fibroblast cells
Comparison
Polyallylamine containing arginine moieties vs Protamine sulfate
Design
Preclinical
Authors
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PAH-ARG may offer improved heparin reversal; in vitro data leave open clinical translation and safety.
Does PAH-ARG reverse heparin-induced aPTT prolongation more effectively than protamine sulfate in preclinical models?
PAH-ARG is a novel, effective, and non-toxic synthetic polymer for heparin reversal that requires half the dose of protamine sulfate in preclinical models.
Kamiński et al. (2014) studied Heparin reversal. PAH-ARG (polyallylamine containing arginine moieties) vs. Protamine sulfate was evaluated on Reduction of activated partial thromboplastin time (aPTT) to normal level. PAH-ARG polymers effectively neutralized heparin and reversed aPTT to normal levels in vitro and in a rat model, requiring half the dose of protamine sulfate.
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