Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement

Figures

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  Figure 1. CONSORT flow chart of surgical patients undergoing aortic valve replacement included in the study. Abbreviations: CKD—chronic kidney disease; eGFR—estimated glomerular filtration rate.

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  Figure 2. Changes in renal function one-week post-SAVR by baseline CKD stage. (A) Post-operative CKD stages by baseline CKD stage, (B) post-operative CKD stage change by baseline CKD stage, (C) post-operative 10% change in eGFR by baseline CKD stage. Abbreviations: CKD—chronic kidney disease; eGFR—estimated glomerular filtration rate.

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  Figure 3. Eight-year Kaplan–Meier survival curves stratified by post-operative renal function change. (A) Survival curves for the following cohorts, measured by stage change: (I) pre-operative stage 1 CKD patients, (II) pre-operative stage 2 CKD patients, (III) pre-operative stage 3 CKD patients. (B) Survival curves for the following cohorts, measured by 10% change in eGFR: (I) pre-operative stage 1 CKD patients, (II) pre-operative stage 2 CKD patients, (III) pre-operative stage 3 CKD patients. * Baseline stage 4 CKD survival curves not shown due to small number of patients. Note: line for baseline stage 1 patients with a 10% improvement in eGFR in graph (B(I)) is truncated at the 5-year mark, due to the number at risk reaching 10 at that time. Abbreviations: CKD—chronic kidney disease; eGFR—estimated glomerular filtration rate.

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  Figure 4. Ten-year Cox cumulative hazard function. (A) Cox function stratified by post-operative CKD stage change. Patients with stable, improved, and deteriorated renal function shown in blue, green, and red, respectively. (*) HR 1.46 (95% CI, 1.22–1.76), (**) HR 0.72 (95% CI, 0.47–1.12). (B) Cox function stratified by post-operative ±10% change in eGFR. Patients with stable, improved, and deteriorated renal function in blue, green and red, respectively. (*) HR 1.35 (95% CI, 1.12–1.63), (**) HR 0.84 (95% CI, 0.60–1.17). Abbreviations: CKD—chronic kidney disease; eGFR—estimated glomerular filtration rate; HR—hazard ratio; CI—confidence interval.