Prolonged and repeated exposure to sublethal doses of total body irradiation induce significant morphologic changes in the mucosa of the small intestine of laboratory animals. These changes include decreased mitosis in the intestinal crypts, necrosis of crypt epithelial cells, and decreased height of crypts and villi (2-5). In man, submucosal fibrosis (6, 7) and mucosal and submucosal lymphangiectasia (8) have been noted together with gastrointestinal malabsorption * Submitted for publication August 26, 1965; accepted
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Trier et al. (1966) studied this question.