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January 1, 1992The Journal of AntibioticsOpen Access

The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

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Authors

MDMichael J. DawsonGranta Design (United Kingdom)JFJohn E. FarthingPMPeter S. MarshallUniversity of Hertfordshire

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Dawson et al. (1992) studied this question.

synapsesocial.com/papers/6a93c52f84ddc81fac7207c9https://doi.org/10.7164/antibiotics.45.639
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.1992 · 154 citations
  2. 2Application of unreactive analogs of terpenoid pyrophosphates to studies of multistep biosynthesis. Demonstration that "presqualene pyrophosphate" is an essential intermediate on the path to squalene1976 · 45 citations
  3. 3Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase1988 · 85 citations
  4. 4Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.1980 · 1,218 citations
  5. 5Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.1980 · 1,637 citations