Key result
Spontaneous heparin reversal successfully manages post-bypass anticoagulation without protamine after severe protamine allergy.
Why the study?
Does spontaneous reversal of heparin prevent allergic complications in a patient with a history of anaphylactoid shock to protamine undergoing cardiopulmonary bypass?
Case Report (n=1)
No
Does spontaneous reversal of heparin prevent allergic complications in a patient with a history of anaphylactoid shock to protamine undergoing cardiopulmonary bypass?
Spontaneous reversal of heparin may be a feasible, though time- and resource-intensive, alternative to protamine in patients with severe protamine allergy undergoing cardiopulmonary bypass.
Spontaneous heparin reversal may avoid protamine allergy during CPB; this single case leaves open questions of safety and reliability.
Protamine은 심폐 우회술 후 heparin의 항응고 작용을 반전시 키기 위해 사용되는 유일한 약물이기는 하나 1) 심한 전신 저혈 압, 아나필락시스 혹은 아나필락시스양 반응과 폐혈관 수축 등 의 심각한 부작용을 야기할 수 있다. 2) 특히 protamine에 대한 아나필락시스
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Lee et al. (2004) conducted a case report in Protamine anaphylactoid shock during cardiopulmonary bypass (n=1). Spontaneous reversal of heparin (omission of protamine) was evaluated. Spontaneous reversal of heparin anticoagulation without the use of protamine was successfully achieved in a patient with a history of anaphylactoid shock to protamine.
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