Key result
LMWH tinzaparin used for routine thromboprophylaxis after total knee replacement was associated with a rare case of skin necrosis.
Case Report (n=1)
This case highlights a rare but severe complication (skin necrosis) associated with the routine use of tinzaparin for VTE prophylaxis after orthopedic surgery.
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Alerts clinicians to rare tinzaparin skin necrosis post-TKR; single case leaves open prophylaxis alternatives.
Thromboprophylaxis are routinely given to prevent venous thromboembolism (VTE) in patients after total hip and knee replacement surgeries. Low molecular weight heparin (LMWH) (fractioned heparin) is effective in the prevention and treatment of VTE. The predicable effect of LMWH has popularized it for routine clinical use. Although LMWH has lesser complication rate, compared to unfractioned heparin (UFH), sporadic clinical complication has been reported. We report a rare case of skin necrosis secondary to use of LMWH tinzaparin used for routine thromboprophylaxis after total knee replacement.
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Karuppiah et al. (2014) conducted a case report in Skin necrosis after total knee replacement (n=1). LMWH tinzaparin was evaluated on Skin necrosis. LMWH tinzaparin used for routine thromboprophylaxis after total knee replacement was associated with a rare case of skin necrosis.
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