Key result
Alcohol consumption ≤80 g/d was inversely associated with carotid intima-media thickness in men (beta=-0.009, P<0.02), but this became insignificant after adjusting for HDL and fibrinogen.
Why the study?
Does alcohol consumption affect subclinical carotid atherosclerosis (intima-media thickness) in a general population?
Observational (n=2,420)
Does alcohol consumption affect subclinical carotid atherosclerosis (intima-media thickness) in a general population?
Effect estimate: beta=-0.009
p-value: p=<0.02
Alcohol consumption has a J-shaped inverse correlation with carotid IMT in men, but the maximum protective effect occurs at daily intake levels associated with severe organ damage.
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Moderate alcohol's inverse link to carotid IMT in men is explained by HDL and fibrinogen; leaves open any direct anti-atherosclerotic effect.
Schminke et al. (2005) conducted an observational in Subclinical carotid atherosclerosis (n=2,420). Alcohol consumption vs. Nondrinkers was evaluated on Carotid intima-media thickness (IMT) (beta=-0.009, p=<0.02). Alcohol consumption ≤80 g/d was inversely associated with carotid intima-media thickness in men (beta=-0.009, P<0.02), but this became insignificant after adjusting for HDL and fibrinogen.
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