Key result
Among 35 patients with adrenal incidentalomas, 32 had nonfunctional masses and 10 required adrenalectomy, emphasizing the need for combined radiological and hormonal evaluation to guide management.
Why the study?
What are the clinical, biochemical, and radiological features of adrenal incidentalomas found on CT/MRI, and how do they guide management?
Observational (n=35)
What are the clinical, biochemical, and radiological features of adrenal incidentalomas found on CT/MRI, and how do they guide management?
Adrenal incidentalomas require systematic hormonal and radiological evaluation to identify malignancy and hypersecretion, which dictates the need for surgical adrenalectomy versus conservative follow-up.
Supports combined evaluation of adrenal incidentalomas; leaves open optimal intervention thresholds pending larger prospective studies.
PURPOSE: To investigate clinical, biochemical and radiological features in 35 patients with adrenal incidentaloma found on CT and/or MRI and to define the management of patients with adrenal masses. MATHERIAL AND METHODS: From January 2011 and May 2013, 35 patients (19F, 16M) with an adrenal mass incidentally discovered on CT and/or MRI were enrolled in a retrospective study. Thirthy-two patients underwent MDCT and eight 1.5 MRI. RESULTS: Patients consisted in 16 males and 19 females, aged between 25 and 89 yo. Adrenal lesions were most commonly found in the sixth decade; in relation to the side of the mass, 20 were found on left side, 15 on the right. Of all the mass analyzed, 3 were <1 cm diameter, 29 between 1 and 4 cm, 3 > 4 cm. The most common finding on CT was adenoma-like appearance (19 cases in relation to size, 14 in relation to attenuation values). Hormonal analysis showed 32 cases of nonfunctional masses and 3 cases of hormone activity. Adrenalectomy was performed in ten patients having adenoma (5 cases), malignant lesions (2 cases), pheocromocitoma, cyst and myelolipoma (1 case). CONCLUSION: Diagnostic approach to adrenal incidentaloma is focused on the definition of malignancy and hormonal activity; the characterization is needs hormonal and radiological (CT and/or MRI) evaluation, even if a fine needle aspiration is needed in selected cases. Benign and/or non-hypersecreting hormone lesion with <4 cm diameter could be sent to follow-up; active adrenal tumors or >4 cm diameter lesions with malignancy suspicious or growth during follow-up could be treated with surgical adrenalectomy.
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Reginelli et al. (2014) conducted an observational in Adrenal incidentaloma (n=35). CT and/or MRI evaluation was evaluated on Clinical, biochemical, and radiological features and management of adrenal masses. Among 35 patients with adrenal incidentalomas, 32 had nonfunctional masses and 10 required adrenalectomy, emphasizing the need for combined radiological and hormonal evaluation to guide management.
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