Key result
Carrying the C allele of the rs3811802 polymorphism in ADH1B was associated with a significantly increased risk of developing colorectal carcinoma (OR 2.136; 95% CI 1.2-3.7; P=0.006).
Why the study?
Is the rs3811802 polymorphism in the promoter region of ADH1B associated with an increased risk of developing colorectal carcinoma in the Chinese Han population?
Case-Control (n=300)
Is the rs3811802 polymorphism in the promoter region of ADH1B associated with an increased risk of developing colorectal carcinoma in the Chinese Han population?
Odds Ratio: 2.136 (95% CI 1.2–3.7)
p-value: p=0.006
The rs3811802 polymorphism in the ADH1B promoter region is associated with increased susceptibility to colorectal carcinoma in the Chinese Han population.
Alcohol dehydrogenase 1B (ADH1B) functions as an oxidase that is involved in the conversion of ethanol to acetaldehyde. Previous studies have shown that ADH1B expression levels are lower in tumor tissues than in adjacent normal tissues in many cancer types. Therefore, the aim of our study was to evaluate the potential association between single nucleotide polymorphisms (SNPs) in the promoter region of ADH1B and the risk of developing colorectal carcinoma (CRC) in the Chinese Han population including 92 CRC patients and 208 controls. The promoter region (−2444 to +14 bp of transcription start site) was sequenced via Sanger sequencing in 92 non-cancerous tissues adjacent to tumor tissues from patients diagnosed with CRC. Eight SNPs were identified in this region and the allele frequencies were compared with that of the Chinese Han population in the 1000 Genomes Project. There was difference in the allele frequency of rs3811802 between the patients with CRC and healthy controls (P=0.006). Subjects carrying allele C had a significant 2.136-fold (95% CI=1.2–3.7) increased risk of developing CRC. Therefore, we suggested that the rs3811802 polymorphism in ADH1B is associated with susceptibility to CRC in the Chinese Han population.
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He et al. (2017) conducted a case-control in Colorectal carcinoma (n=300). rs3811802 polymorphism in ADH1B (allele C) vs. Healthy controls / non-carriers was evaluated on Risk of developing colorectal carcinoma (OR 2.136, 95% CI 1.2-3.7, p=0.006). Carrying the C allele of the rs3811802 polymorphism in ADH1B was associated with a significantly increased risk of developing colorectal carcinoma (OR 2.136; 95% CI 1.2-3.7; P=0.006).
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