Key result
In elderly patients with NHL treated with CHOP chemotherapy, poor performance status (ECOG 2 to 4) was the only independent predictor of treatment-related death (RR 3.52; 95% CI 2.98 to 4.06).
Why the study?
What are the risk factors for treatment-related death in elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy?
Cohort (n=267)
No
What are the risk factors for treatment-related death in elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy?
Relative Risk: 3.52 (95% CI 2.98–4.06)
In elderly patients with aggressive NHL treated with CHOP chemotherapy, poor performance status, rather than chronologic age, is the primary independent predictor of treatment-related death.
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May guide PS-based risk assessment over age in elderly NHL on CHOP; leaves open prospective validation before changing eligibility.
Gómez et al. (1998) conducted a cohort in Intermediate- or high-grade non-Hodgkin's lymphoma (n=267). Poor performance status (ECOG 2 to 4) vs. Good performance status (ECOG 0 to 1) was evaluated on Treatment-related death (RR 3.52, 95% CI 2.98 to 4.06). In elderly patients with NHL treated with CHOP chemotherapy, poor performance status (ECOG 2 to 4) was the only independent predictor of treatment-related death (RR 3.52; 95% CI 2.98 to 4.06).
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